In the effect of DDS on multiplication of Mycobaterium leprae in mouse foot-pads
from previously untreated patients with lepromatous leprosy and relapsed patients under
treaiment with DDS alone, the following results were obtained. Among eight new cases,
suppression of multiplication with three different DDS mouse diets of 0.01%, 0.001% and
0.0001% was shown in 2 cases, multiplication of Mycobaterium leprae with 0.02% DDS
diet shown in 2 cases, with 0.001% DDS diet in one case and with 0.0001% DDS diet in
3 cases. These six cases shown multiplication of Mycobaterium leprae in the foot-pads
of ddy mice fed with DDS diet may be considered as primary DDS resistance. Among
four relapse cases, multiplication of Mycobaterium leprae with 0.01% DDS diet was
shown in 3 cases and multiplication with 0.0001% DDS diet shown in 1 case. These
cases are surely considered as secondary DDS resistance. From the above experimental
results, it might be suggested that the value of DDS effectiveness in the treatment of
leprosy is significantly reduced nowadays than ever before. Therefore, DDS resistance is
recently erupted as a serious problem in the leprosy control in the country.
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